We are at a phase in this world when our ideas and past concepts are shattered with new ones. Views about many things have changed over the years all thanks to the researches and struggles of the professionals. In different fields, new things are coming up frequently rendering the existing products and services useless. It is a world where we need to update ourselves every day in order to have knowledge about everyday things. Our everyday things are no longer just contained within food and clothes. Development and modernization have led us to feel the necessity of many items that are designed to make life a bit easier. Modern time is constantly trying find solutions to enable better living as well as health. Researches are going on in order to find better medicines and procedures for different health issues. These researchers have found a solution within human body itself. This solution to multiple issues is called the peptides. There are quite a few peptides which are found in him and body while some of these are artificially made. With lots of benefits to offer peptides happen to be the house of wonders.
The big protein family of human Cathelicidin has quite a few peptides that performs diverse function in the body. LL-37 is known as the only human Cathelicidin. Two types of blood cells- polymorphonuclear and macrophages leucocytes produce these peptides with bacterial action. This entire group of peptides is often called AMPs or antimicrobial peptides. LL-37 is known to have roles to play in wound healing, cancer and autoimmune disease.
Intestinal cancer and the role of LL-37
It was revealed in cell-culture based findings that LL-37 has multiple functions to do in the intestine. Cell migration is necessary for the maintenance of epithelial barrier of the intestine and this peptide improves cell migration. In case of intestinal inflammation, LL-37 is capable of reducing the causes and related pathogenesis of inflammation in the intestine by reducing apoptosis. This peptide can also be a part of treatment for inflammatory bowel conditions. This peptide can also provide treatment during acute intestinal infections, post intestinal surgeries and also as an oral antibiotic preventing GI side effects. In felicitates wound healing by pairing with beta-defensin 2. Along with maintaining intestinal epithelium, it also decreases TNF-related cell death. TNF-alpha inhibitors are primary treatment for inflammatory bowel disease. But the uses of these drugs include side effects like increasing chances of tuberculosis. LL-37 is capable of reducing TNF-alpha dependance.
Arthritis and LL-37 peptide
Rat models suffering from rheumatoid arthritis had higher level of LL-37 in the joints. Though it is not yet confirmed if this is a cure or cause of pain, the peptide’s ability to fight inflammation gives some hope.
This peptide has different isoforms in different animals including human beings. It increases the chances of achieving specific outcome through amino acid modulation. This peptide with minimal to moderate side effects has excellent subcutaneous bioavailability. LL-37 peptide online is available for research purposes and licensed researchers can avail it for laboratory usage.
